NSAID, fenamate series. Primary dysmenorrhoea, menorrhagia; mild-mod pain eg dental, soft tissue

Precautions:

CV disease, risk factors; hypertension (monitor); cardiac, hepatic impairment (monitor); fluid retention sensitive conditions; asthma; chronic urticaria; GI event risk factors eg smoking, alcoholism, GI ulceration/ bleeding history; prerenal conditions eg nephrotic syndrome (monitor); high dose, prolonged use; elderly; pregnancy (esp 3rd trimester)

Adverse Reactions:

GI upset incl ulceration; incr risk MI, stroke; hypertension/ hypotension; oedema; incr LFTs; glucose intolerance; hyponatraemia; nervousness; vision disturbance; blood dyscrasia; asthma; convulsion; palpitation; renal failure; serious skin reactions eg SJS, TEN; anaphylaxis; others, Ask your Phamacist for more details

Interactions:

See Contra; aspirin, anticoagulants eg warfarin; IUCD (poss); methotrexate; Li; hypoglycaemics; cyclosporin; tacrolimus; corticosteroids; antihypertensives; ACE inhibitor/ angiotensin receptor antagonist + anti-inflammatory + diuretic (Ask your Phamacist for more details); lab tests (urinary bile diazo tablet)

Dose:

Use lowest effective dose for shortest poss duration. Dysmenorrhoea: 2 cap (500 mg) 3 times daily from onset of pain; continue for usual duration of pain. Menorrhagia: 2 cap (500 mg) 3 times daily from onset of menses; max 7 days unless on doctor's advice. Other: 2 cap (500 mg) 3 times daily